What question did this study set out to answer?

This study aims to examine how regional myocardial perfusion relates to asynergy in coronary heart disease patients.

November 1, 1978CirculationOpen Access

Relationship between regional myocardial perfusion and the presence, severity and reversibility of asynergy in patients with coronary heart disease.

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Why the study?

What is the relationship between regional myocardial perfusion and the presence, severity, and reversibility of asynergy in patients with coronary heart disease?

Population

45 patients undergoing cardiac catheterization (13 normal, 32 with coronary heart disease)

Design

Cross-sectional

Authors

MBMonty BodenheimerWestern University VBVidya S. BankaUPMC Presbyterian CFColleen M. FoosheeSan Diego State University

Discussion

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Implication

Links perfusion defects to asynergy in CHD; hypothesis-generating and requires prospective validation before clinical use.

Key Points

This study aims to examine how regional myocardial perfusion relates to asynergy in coronary heart disease patients.
Utilized thallium-201 exercise testing and cardiac catheterization in 45 patients.
Assessed coronary arteriography and intervention effects using nitroglycerin.
Classified left ventricular zones based on myocardial perfusion abnormalities post-exercise.
18 of 21 patients with asynergy had myocardial perfusion abnormalities after exercise (P < 0.001).
All akinetic and dyskinetic zones showed perfusion defects, while 67% of hypokinetic zones did (P < 0.025).
There was a significant relationship between coronary arterial obstruction severity, asynergy presence, and perfusion abnormalities.

Structured PICO

What is the relationship between regional myocardial perfusion and the presence, severity, and reversibility of asynergy in patients with coronary heart disease?

Population

45 patients undergoing cardiac catheterization (13 normal, 32 with coronary heart disease)

Intervention

Exercise testing with thallium-201, cardiac catheterization including nitroglycerin ventriculography and coronary arteriography

Outcome

Relationship between regional myocardial perfusion at rest and after exercise, the presence, severity and reversibility of asynergy, and the severity of coronary arterial obstructionsurrogate

Regional myocardial perfusion abnormalities after exercise correlate strongly with the presence and severity of ventricular asynergy, and reversible asynergy is associated with normal or improved resting perfusion.

Cite This Study

Bodenheimer et al. (1978) studied this question.

synapsesocial.com/papers/6a20b9fef9039b2a31e4e4bb https://doi.org/10.1161/01.cir.58.5.789

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Relationship between regional myocardial perfusion and the presence, severity and reversibility of asynergy in patients with coronary heart disease.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Relationship between regional myocardial perfusion and the presence, severity and reversibility of asynergy in patients with coronary heart disease.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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