Key result
Left atrial appendage pacing in dogs separated the Marshall potential from the atrial electrogram, presenting with a prolonged AM interval (125±9 vs 80±6 ms, P=0.043 at pacing rate 350).
Why the study?
Does left atrial appendage pacing alter the electrophysiological characteristics of the Marshall potential compared to sinus rhythm in a canine model?
Does left atrial appendage pacing alter the electrophysiological characteristics of the Marshall potential compared to sinus rhythm in a canine model?
Left atrial appendage pacing prolongs the AM interval and separates the Marshall potential from the atrial electrogram, which may facilitate ligament of Marshall ablation.
Answers are grounded in this paper and cite their sources.
May aid Marshall bundle mapping during ablation; leaves open clinical translation from this canine model.
Background: The electrophysiological characteristics of the Marshall potential is important in ligament of Marshall (LOM) ablation. Methods and Results: Marshall potential was recorded under sinus rhythm and left atrial appendage (LAA) pacing and in the first randomly selected 5 dogs (Group 1), LOM ablation was performed. Histological examination was performed in the remaining 10 dogs, which were subdivided according to the results (Groups 2, 3). During LAA pacing in Group 2, the AM interval was prolonged or shortened, whereas in Group 3 it was prolonged (125±9 vs 80±6 ms, P=0.043, when the pacing rate =350) (126±9 vs 80±6 ms, P=0.0442, when the pacing rate =450). The Marshall potential was separated from the atrial electrogram by LAA pacing in Groups 2 and 3. There was no significant difference in the AM interval during sinus rhythm and right atrial appendage pacing. Conclusions: Marshall potential has different forms on electrograms, including a prolonged AM interval, which presents with LAA pacing. This finding might be useful in LOM ablation. (Circ J 2009; 73: 444 - 450)
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Lei et al. (2009) studied Ligament of Marshall electrophysiology (n=15). Left atrial appendage (LAA) pacing vs. Sinus rhythm and right atrial appendage pacing was evaluated on AM interval during LAA pacing (p=0.043). Left atrial appendage pacing in dogs separated the Marshall potential from the atrial electrogram, presenting with a prolonged AM interval (125±9 vs 80±6 ms, P=0.043 at pacing rate 350).
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