Key result
Increasing left atrial diameter was associated with stroke and thromboembolic events in patients without atrial fibrillation (RR 1.38; 95% CI 1.02-1.87), but not in those with AF (p for diff=0.05).
Why the study?
The prognostic value of left atrial dimensions may differ between patients with and without AF.
Does increasing left atrial dimension predict cardiovascular outcomes differently in patients with and without atrial fibrillation?
Comparison
Increasing echocardiographic LA parameters vs lower parameters
Design
Systematic review and random-effects meta-analysis
Authors
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May warrant LA size evaluation for stroke risk in sinus rhythm; extends prognostic role of LA diameter beyond AF.
Meta-Analysis (n=65,659)
Does increasing left atrial dimension predict cardiovascular outcomes differently in patients with and without atrial fibrillation?
Effect estimate: RR 1.38 (without AF) (95% CI 1.02-1.87)
p-value: p=0.03
Larger left atrial parameters are associated with adverse cardiovascular events, with stronger associations in individuals without atrial fibrillation, highlighting the prognostic importance of LA myopathy.
Froehlich et al. (2019) conducted a meta-analysis in Atrial fibrillation (n=65,659). Increasing left atrial diameter was evaluated on Incident stroke or thromboembolic events (RR 1.38 (without AF), 95% CI 1.02-1.87, p=0.03). Increasing left atrial diameter was associated with stroke and thromboembolic events in patients without atrial fibrillation (RR 1.38; 95% CI 1.02-1.87), but not in those with AF (p for diff=0.05).
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