Key result
Synergistic targeting of MMP-2 activity and its proteolytic action on cardiac contractile proteins represents a promising preventive therapeutic strategy against ischemia/reperfusion injury.
This review highlights a novel preclinical therapeutic concept of using synergy to target MMP-2 activity and prevent MLC 1 degradation during cardiac ischemia/reperfusion injury.
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MMP-2 synergy may prevent ischemia/reperfusion injury; leaves open clinical translation from preclinical models.
Cadete et al. (2013) conducted a review in Cardiac ischemia/reperfusion injury. Synergistic targeting of MMP-2 activity was evaluated. Synergistic targeting of MMP-2 activity and its proteolytic action on cardiac contractile proteins represents a promising preventive therapeutic strategy against ischemia/reperfusion injury.
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