What does this research mean for the field?

A ~20,000-dalton glycoprotein isolated from bovine brain inhibits the actin-stimulated Mg-ATPase activity of striated muscle myosin by inducing actin depolymerization and preventing its polymerization. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1983Journal of Neurochemistry

Actin‐Stimulated Myosin Mg2+‐ATPase Inhibition by Brain Protein

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Population

In vitro model using low-molecular-weight protein isolated from bovine brain and myosin/actin from striated…

Design

Preclinical

Authors

SBS. BerlAugusta University MCMei ChouUniversity of British Columbia CMCatherine MytilineouIcahn School of Medicine at Mount Sinai

Discussion

Member takes

Implication

Identifies a bovine brain actin-depolymerizing glycoprotein; leaves open any role in cardiac myofilament regulation or human disease.

Structured PICO

Population

In vitro model using low-molecular-weight protein isolated from bovine brain and myosin/actin from striated muscle

Intervention

Low-molecular-weight protein (approx 20,000 daltons, heat-labile glycoprotein) from bovine brain

Outcome

Inhibition of actin-stimulated Mg-ATPase activity of myosinsurrogate

A 20,000-dalton glycoprotein isolated from bovine brain inhibits actin-stimulated myosin Mg-ATPase activity by depolymerizing actin.

Cite This Study

Berl et al. (1983) studied this question.

synapsesocial.com/papers/6a1628d2b67720c279c1ec65 https://doi.org/10.1111/j.1471-4159.1983.tb13582.x

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Actin‐Stimulated Myosin Mg2+‐ATPase Inhibition by Brain Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Actin‐Stimulated Myosin Mg2+‐ATPase Inhibition by Brain Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider