Factors Influencing the Outcome of Thrombolysis in Acute Myocardial Infarction

Coronary heart disease (CHD) is a worldwide health epidemic. It has been defined as “impairment of heart function due to inadequate blood flow to heart compared to its needs caused by obstructive changes in the coronary circulation to the heart”(1). It is the cause of 25-30% of deaths in most of the industrialized countries. In India also it is a major public health problem. It is aptly called by WHO as the 'modern epidemic'. The increasing incidence of coronary heart disease may be a reflection of increased longevity, adoption of high fat diet based on meats decreased exercise, modern lifestyle, made possible by increasing affluence.The present study is to ascertain the factors influencing outcome of thrombolysis in acute MI and concludes that Gender and Pre infarction not influence the success rate of thrombolysis, Better success rate has been seen in those consuming alcohol and smokers had a lesser success rate than non smokers but statistically not significant. Hypertensives did not show any difference with non hypertensives in the success rate. Diabetics did not differ much from non diabetics with respect to the success rate of thrombolysis. Inferior wall myocardial infarction had a better success rate than anterior wall myocardial infarctions. Those who are having short window period had a better success rate after thrombolysis. Shorter the window period higher the success rate.