Key result
Late presentation and persistence of chest pain were significantly associated with failed thrombolysis in AMI, with a longer mean time for chest pain resolution (3.55 vs 1.98 hours).
Why the study?
What are the demographic and clinical predictors of failed thrombolysis in patients with acute myocardial infarction?
Observational (n=50)
What are the demographic and clinical predictors of failed thrombolysis in patients with acute myocardial infarction?
Late presentation, persistence of chest pain, and non-resolution of reciprocal ST depression are significant clinical predictors of failed thrombolysis in patients with acute myocardial infarction.
May guide risk stratification for failed thrombolysis in AMI; hypothesis-generating and requires prospective validation before clinical adoption.
objectives: Acute myocardial infarction(AMI) is becoming increasingly important problem in developing countries, and thrombolysis is the main modality of treatment here. About 25-50% of patients fail to achieve successful reperfusion and these patients have poor prognosis. Since alternative modes of reperfusion are available, it is important to identify them. This study was aimed at defining the extent of failed thrombolysis and identifying its demographic and clinical predictorsMethods: 50 cases of thrombolysed AMI patients were studied. Failed thrombolysis considered if there is 0.05), percentage of females was 25% v/s 16.7%(P>0.05), mean time for resolution of chest pain was 3.55±1.1 hrs v/s. 1.98±0.93 hrs (P 0.05), inferior wall MI was 30% v/s 46% (P>0.05) in failed and successful group respectivly. Interpretation and conclusion.Late presentation is an important risk factor for failed thrombolysis in AMI. Persistence of chest pain and non-resolution of reciprocal ST depression are significantly associated with failed thrombolysis.
No takes yet. Share an insight, caveat, or question.
Rao et al. (2012) conducted an observational in Acute myocardial infarction (n=50). Late presentation and clinical factors vs. Absence of these risk factors was evaluated on Failed thrombolysis. Late presentation and persistence of chest pain were significantly associated with failed thrombolysis in AMI, with a longer mean time for chest pain resolution (3.55 vs 1.98 hours).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: