Key result
SVG failure progresses through three distinct phases driven by inflammatory and prothrombotic cascades.
Why the study?
The great saphenous vein remains the most used conduit for CABG but is susceptible to short- and long-term failure from acute thrombosis, intimal hyperplasia, and superimposed atheroma.
This review outlines the three-phase pathophysiology of saphenous vein graft failure and highlights the role of surgical techniques and secondary pharmaceutical prevention in reducing its incidence.
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Highlights potential prevention targets post-CABG; leaves open validation of phase-specific interventions in prospective trials.
Guida et al. (2022) conducted a review in Saphenous vein graft failure. Saphenous vein graft failure progresses through three distinct phases—acute thrombosis, intimal hyperplasia, and accelerated atherosclerosis—driven by inflammatory and prothrombotic cascades.
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