Key result
Pharmacological testing with adenosine triphosphate inhibited ventricular tachycardia and premature ventricular contractions in all 6 patients, suggesting a cAMP-mediated triggered activity mechanism.
Why the study?
What are the autonomic and pharmacological responses of idiopathic ventricular tachycardia arising from the left ventricular outflow tract?
Population
6 patients with idiopathic ventricular tachycardia or premature ventricular contractions arising from the…
Design
Case_series
Authors
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May support mechanism-guided therapy in LVOT VT; extends RVOT observations but leaves open need for prospective validation.
Observational (n=6)
What are the autonomic and pharmacological responses of idiopathic ventricular tachycardia arising from the left ventricular outflow tract?
The mechanism of idiopathic VT arising from the LVOT is likely due to cAMP-mediated triggered activity, similar to RVOT VT, based on its response to autonomic and pharmacological interventions.
Yamawake et al. (2007) conducted an observational in Idiopathic ventricular tachycardia arising from the left ventricular outflow tract (n=6). Autonomic modulations and pharmacological interventions (isoproterenol, ATP, propranolol, lidocaine, procainamide, verapamil) was evaluated on Response of ventricular tachycardia and premature ventricular contractions to autonomic and pharmacological interventions. Pharmacological testing with adenosine triphosphate inhibited ventricular tachycardia and premature ventricular contractions in all 6 patients, suggesting a cAMP-mediated triggered activity mechanism.
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