Why the study?
Does intramuscular diclofenac prolong skin bleeding time and reduce platelet aggregation in thoracotomy patients?
Does intramuscular diclofenac prolong skin bleeding time and reduce platelet aggregation in thoracotomy patients?
Intramuscular diclofenac administered at anesthesia induction significantly impairs platelet function and prolongs bleeding time.
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Clinicians should exercise caution with perioperative IM diclofenac due to hemostatic impairment; confirms antiplatelet effects in thoracotomy RCT.
A randomised double-blind controlled study was performed to examine the effect of diclofenac on skin bleeding time and in vitro whole blood platelet aggregation. Twenty thoracotomy patients were studied; 10 were given diclofenac 75 mg intramuscularly at induction of anaesthesia, and 10 formed a control group. Skin bleeding times and platelet aggregation tests were performed the day before and repeated one hour after induction of anaesthesia. Diclofenac prolonged skin bleeding time and reduced platelet aggregation. There were no significant changes in the control group.
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Power et al. (1990) studied this question.
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