Key result
Randomized controlled trials have not shown a lower blood pressure target to offer significant clinical benefit over standard targets, and suggest potential harm with overly aggressive therapy.
Why the study?
Does intensive blood pressure lowering to specific lower targets improve cardiovascular and renal outcomes in adults with hypertension compared to standard targets?
Does intensive blood pressure lowering to specific lower targets improve cardiovascular and renal outcomes in adults with hypertension compared to standard targets?
Targeting strict lower blood pressure goals does not consistently improve cardiovascular or renal outcomes and may increase adverse events, suggesting that individualized therapy is preferable to universal strict targets.
Supports avoiding overly aggressive BP targets; leaves open optimal strategies for specific high-risk groups.
At least 16 treatment trials have been done in which patients were randomly assigned different blood pressure goals in an attempt to better define specific target pressures. We critically review the data.
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Filippone et al. (2011) conducted a review in Hypertension. Intensive blood pressure lowering (lower target) vs. Standard blood pressure lowering (higher target) was evaluated on Cardiovascular and renal events. Randomized controlled trials have not shown a lower blood pressure target to offer significant clinical benefit over standard targets, and suggest potential harm with overly aggressive therapy.
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