What question did this study set out to answer?

Evaluate the role of primary cilia as ubiquitous sensory cellular organelles and assess modern detection methods across normal and diseased states.

October 8, 2008Pathobiology

Primary Cilia in Normal and Pathological Tissues

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Evaluate the role of primary cilia as ubiquitous sensory cellular organelles and assess modern detection methods across normal and diseased states.
Reviewed historical pathology literature documenting primary cilia identification via conventional electron microscopy.
Examined antibody-based immunostaining targeting detyrosinated tubulin for rapid, systematic identification and statistical evaluation of cilia.
Primary cilia represent regular sensory transducer organelles essential for cell signaling rather than atypical cellular artifacts.
Antibody labeling against detyrosinated tubulin substantially accelerates detection, frequency calculation, and structural characterization compared to slow electron microscopy methods.

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Implication

Narrative review reveals regular sensory transducer functions of primary cilia in healthy and diseased tissues, highlighting immunostaining methods for clinical and pathological evaluation.

Cite This Study

Denys N. Wheatley (2008) studied this question.

synapsesocial.com/papers/6a16469df9339c53aa8eb13a https://doi.org/10.1159/000163955

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Implication

Narrative review reveals regular sensory transducer functions of primary cilia in healthy and diseased tissues, highlighting immunostaining methods for clinical and pathological evaluation.

Primary Cilia in Normal and Pathological Tissues

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Discussion

Implication

Cite This Study

Primary Cilia in Normal and Pathological Tissues

Key Points

Discussion

Implication

Cite This Study

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