What question did this study set out to answer?

To identify the physiological and behavioral determinants of metabolically healthy obese and at-risk normal-weight phenotypes in Black South African women.

April 17, 2008ObesityOpen Access

Determinants of Insulin‐resistant Phenotypes in Normal‐weight and Obese Black African Women

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Authors

CJCourtney JenningsCleveland Clinic ELEstelle V. LambertUniversity of Cape Town MCMalcolm CollinsDepartment of Physiological Sciences

Discussion

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Implication

Cross-sectional study uncovers determinants of insulin resistance in normal-weight and obese Black African women, highlighting the role of visceral fat distribution.

Key Points

To identify the physiological and behavioral determinants of metabolically healthy obese and at-risk normal-weight phenotypes in Black South African women.
Assessed body composition, fat distribution, blood pressure, fasting glucose, lipid profiles, and socio-demographics in 103 normal-weight (BMI ≤ 25 kg/m²) and 122 obese (BMI ≥ 30 kg/m²) Black South African women.
Categorized participants as insulin sensitive or insulin resistant using the homeostasis model assessment of insulin resistance (HOMA-IR ≥ 1.95 defining resistance).
Insulin resistance occurred in 22% of normal-weight women, whereas 38% of obese women remained insulin sensitive.
Higher visceral adipose tissue (P=0.001) and lower visceral adipose tissue to leg fat mass ratios (P≤0.001) distinguished insulin-resistant from insulin-sensitive phenotypes independently of total adiposity.
Body fat distribution, body fat percentage, age, injectable contraception use, and leisure physical activity energy expenditure explained 35% of HOMA-IR variance in normal-weight women and 34% in obese women (excluding physical activity).

Cite This Study

Jennings et al. (2008) studied this question.

synapsesocial.com/papers/6a164b20ed257bd69ec526ae https://doi.org/10.1038/oby.2008.233

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Implication

Cross-sectional study uncovers determinants of insulin resistance in normal-weight and obese Black African women, highlighting the role of visceral fat distribution.

Determinants of Insulin‐resistant Phenotypes in Normal‐weight and Obese Black African Women

Discussion

Member takes

Implication

Key Points

Cite This Study

Determinants of Insulin‐resistant Phenotypes in Normal‐weight and Obese Black African Women

Discussion

Member takes

Implication

Key Points

Cite This Study

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