Key result
Co-clustered obesity, hypertension, and diabetes linked to worse cardiac remodeling and ~34% greater LV mass.
Why the study?
Obesity, hypertension, and diabetes independently associate with cardiac remodeling and frequently co-cluster, but their conjoint and separate influences on cardiac remodeling have not been investigated.
Does the co-clustering of obesity, diabetes, and hypertension worsen indices of ventricular remodeling in a community-based cohort?
Population
5,741 Framingham Study participants
Comparison
Cross-classified categories of BMI, hypertension, and diabetes
Design
Community-based observational study
Authors
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May warrant closer monitoring in clustered patients; hypothesis-generating for intervention trials on remodeling.
Observational (n=5,741)
Does the co-clustering of obesity, diabetes, and hypertension worsen indices of ventricular remodeling in a community-based cohort?
p-value: p=<0.01
Obesity, hypertension, and diabetes interact synergistically to worsen cardiac remodeling, particularly increasing LV mass and worsening global longitudinal strain.
Jeinsen et al. (2020) conducted an observational in Cardiac remodeling (n=5,741). Obesity, hypertension, and diabetes vs. Normal BMI without hypertension or diabetes was evaluated on Left ventricular mass, LV ejection fraction, global longitudinal strain, and left atrial emptying fraction (p=<0.01). Co-clustering of obesity, hypertension, and diabetes synergistically worsened cardiac remodeling, increasing left ventricular mass by 34% and worsening global longitudinal strain by 9% (p<0.01).
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