Key result
Benidipine significantly increased flow-mediated dilatation from 4.7% to 7.4% (P<0.05) in patients with coronary vasospasm, whereas diltiazem and verapamil had no effect.
Why the study?
Does benidipine improve vascular endothelial function compared to diltiazem or verapamil in patients with coronary spastic angina?
Population
25 normotensive patients with coronary spastic angina documented by acetylcholine provocation test, with…
Comparison
Benidipine 8 mg/day for 3 months vs Diltiazem 200 mg/day or verapamil 120 mg/day for…
Design
RCT, randomized to 1 of 3 CCB groups, All arterial diameters were measured by…
Follow-up
3 months
Authors
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Benidipine may be preferred over diltiazem or verapamil in coronary vasospasm; extends evidence for differential endothelial effects among calcium-channel blockers.
RCT (n=25)
Randomized
Does benidipine improve vascular endothelial function compared to diltiazem or verapamil in patients with coronary spastic angina?
p-value: p=<0.05
In patients with coronary spastic angina, the dihydropyridine calcium-channel blocker benidipine significantly improved endothelial function and increased NO production, unlike the non-dihydropyridines diltiazem or verapamil.
Miwa et al. (2009) conducted an RCT in Coronary spastic angina (n=25). Benidipine vs. Diltiazem and verapamil was evaluated on Endothelium-dependent flow-mediated dilatation (FMD) (p=<0.05). Benidipine significantly increased flow-mediated dilatation from 4.7% to 7.4% (P<0.05) in patients with coronary vasospasm, whereas diltiazem and verapamil had no effect.
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