Key result
Benidipine tended to lower cardiovascular events compared with diltiazem and amlodipine, and significantly reduced vascular infarction events versus diltiazem in patients with vasospastic angina.
Why the study?
Does benidipine reduce cardiovascular events in patients with vasospastic angina compared to diltiazem and amlodipine?
Cohort (n=527)
Does benidipine reduce cardiovascular events in patients with vasospastic angina compared to diltiazem and amlodipine?
Benidipine may be more effective than diltiazem and amlodipine in reducing vascular infarction and cardiovascular events in patients with vasospastic angina.
May support benidipine preference in vasospastic angina; hypothesis-generating and requires randomized confirmation.
We have previously reported the changing clinical characteristics of patients with vasospastic angina (VSA) before and after the introduction of new calcium channel blockers (benidipine and amlodipine) in 1990. In this subanalysis study, we compared the prognostic effects of 3 calcium channel blockers (benidipine, diltiazem, and amlodipine) on the incidence of cardiovascular events in patients with VSA in our cohort study, where 527 patients (318 men and 209 women) enrolled after 1990 (from January 1990 to December 2002) were followed-up for a mean period of 5.2 years. There was no significant difference in the clinical characteristics among the 3 calcium channel blocker groups. Multivariate analysis demonstrated that 4 factors, including smoking, hypertension, diabetes mellitus and reduced left ventricular ejection fraction, were significant risk factors for cardiovascular events. Among the 3 calcium channel blockers examined, benidipine (n = 148) tended to be associated with a lower incidence of total events, cardiovascular events, and cerebral infarction, compared with diltiazem (n = 313) and amlodipine (n = 111). Furthermore, benidipine significantly reduced the incidence of vascular infarction events, a possible indicator of atherosclerosis, as compared with diltiazem. These results suggest that benidipine may be more useful for the treatment of VSA as compared with diltiazem and amlodipine.
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Fukumoto et al. (2008) conducted a cohort in Vasospastic angina (VSA) (n=527). Benidipine vs. Diltiazem and Amlodipine was evaluated on Incidence of cardiovascular events. Benidipine tended to lower cardiovascular events compared with diltiazem and amlodipine, and significantly reduced vascular infarction events versus diltiazem in patients with vasospastic angina.