September 28, 2004Journal of Cardiovascular Pharmacology
Changing Characteristics of Patients with Vasospastic Angina in the Era of New Calcium Channel Blockers
Key result
Survival without cardiovascular events at 5 years in patients with vasospastic angina was 96% both before and after 1990, with benidipine showing a better prognosis among calcium channel blockers.
Why the study?
Does the introduction of new calcium channel blockers (benidipine and amlodipine) alter the long-term prognosis and prognostic factors of patients with vasospastic angina?
Population
726 patients with vasospastic angina registered from January 1980 to December 2002
Comparison
Treatment with new calcium channel blockers vs Historical cohort treated before 1990
Design
Cohort
Follow-up
5 years
Authors
Discussion
Loading...
Member takes
Implication
Updated VSA prognosis data after newer CCB introduction; leaves open whether benidipine or amlodipine alters long-term outcomes.
Study Design
Type
Cohort (n=726)
Structured PICO
Does the introduction of new calcium channel blockers (benidipine and amlodipine) alter the long-term prognosis and prognostic factors of patients with vasospastic angina?
P
Population
726 patients with vasospastic angina registered between 1980 and 2002, with a 92% follow-up rate.
E
Exposure
Treatment with new calcium channel blockers (benidipine and amlodipine, used in 28% and 21% of patients respectively after 1990)
C
Comparator
Historical cohort treated before 1990 (prior to the introduction of new calcium channel blockers)
O
Outcome
Survival without cardiovascular events at 5 yearshard clinical
Main Result
Absolute Event Rate: 96% vs 96%
The long-term prognosis of vasospastic angina remains excellent in the era of new calcium channel blockers, though risk factors like diabetes, smoking, and prior MI have become more influential prognosticators.
Cite This Study
Itô et al. (2004) conducted a cohort in Vasospastic angina (n=726). Era after 1990 (introduction of new calcium channel blockers) vs. Era before 1990 was evaluated on Survival without cardiovascular events at 5 years. Survival without cardiovascular events at 5 years in patients with vasospastic angina was 96% both before and after 1990, with benidipine showing a better prognosis among calcium channel blockers.