Higher Life's Essential 8 scores were inversely associated with diabetic retinopathy prevalence, with high scores reducing the odds by 76% compared to low scores (OR 0.24).
Cross-Sectional (n=1,458)
Is higher cardiovascular health (assessed by Life's Essential 8) associated with a lower prevalence of diabetic retinopathy?
Higher cardiovascular health, as measured by Life's Essential 8, is associated with a lower prevalence of diabetic retinopathy, an effect partially mediated by biological and phenotypic aging.
Effect estimate: OR 0.24 (95% CI 0.11-0.50)
p-value: p=<0.001
BACKGROUND: The American Heart Association (AHA) recently updated the Life's Essential 8 (LE8) metrics to measure ideal cardiovascular health (CVH). Diabetic retinopathy (DR) is the leading cause of vision impairment, exhibiting a rising prevalence globally. However, the association between LE8 and DR, as well as the mediating role of phenotypic age (PA) and biological age (BA), is still unclear. METHODS: LE8 scores were categorized into three groups: low (0-49), moderate (50-74), and high (75-100). PA and BA were computed using validated algorithms incorporating clinical biomarkers. Weighted logistic regression and linear analysis were employed to assess the relationship between LE8 and DR. The mediation analysis was conducted to explore the mediating role of PA and BA. RESULTS: Our study included 1129 participants with non-DR and 329 participants with DR from the National Health and Nutrition Examination Survey (NHANES). Higher LE8 scores were inversely associated with DR prevalence after adjusting for all covariates (OR = 0.24; 95% CI: 0.11-0.50; P for trend < 0.001). Each 10-point LE8 increase was related to a 23% decrease of DR (OR = 0.77, 95% CI: 0.69-0.84). Mediation analysis indicated that PA and BA partially mediated 35.61% and 46.38% of the association between LE8 and DR, respectively. CONCLUSIONS: The LE8 scores were negatively associated with the incidence of DR, while PA and BA partially mediated the association between LE8 scores and DR.
Wang et al. (Tue,) conducted a cross-sectional in Diabetic retinopathy in patients with diabetes (n=1,458). High Life's Essential 8 (LE8) score vs. Low LE8 score (0-49 points) was evaluated on Prevalence of diabetic retinopathy (OR 0.24, 95% CI 0.11-0.50, p=<0.001). Higher Life's Essential 8 scores were inversely associated with diabetic retinopathy prevalence, with high scores reducing the odds by 76% compared to low scores (OR 0.24).