Key result
Vascular permeability factor, histamine, and serotonin stimulated macromolecule extravasation via vesiculo-vacuolar organelles, which occupied 16-18% of endothelial cytoplasm in normal venules.
Population
Normal animals
Comparison
Intradermal injection of vascular permeability… vs Unstimulated normal venules (implied baseline)
Design
Preclinical
Authors
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Should not alter clinical permeability management; extends VVO observations from tumors to normal venules but remains hypothesis-generating.
This study identifies vesiculo-vacuolar organelles (VVOs) as the primary structural pathway through which vascular permeability factor, histamine, and serotonin induce macromolecular leakage in venules.
Feng et al. (1996) studied Vascular hyperpermeability. Vascular permeability factor (VPF), histamine, and serotonin was evaluated on Extravasation of macromolecular tracer (ferritin). Vascular permeability factor, histamine, and serotonin stimulated macromolecule extravasation via vesiculo-vacuolar organelles, which occupied 16-18% of endothelial cytoplasm in normal venules.
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