VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor

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Why the study?

Does VEGF increase vascular permeability via PAF synthesis in rats and bovine endothelial cells?

Structured PICO

Does VEGF increase vascular permeability via PAF synthesis in rats and bovine endothelial cells?

Population

Rats (in vivo) and cultured bovine aortic endothelial cells (in vitro)

Intervention

Intravenous injection of VEGF (0.001-0.1 nmol/kg) in rats; VEGF (10(-11) to 10(-9) M) in cultured cells

Comparator

Control levels

Outcome

Protein extravasation (vascular permeability) in rats and PAF synthesis in cultured cellssurrogate

VEGF increases vascular permeability by inducing the synthesis of platelet-activating factor (PAF).

No takes yet. Share an insight, caveat, or question.

PAF antagonists may blunt VEGF permeability in preclinical models; leaves open translation to human edema syndromes.

Sirois et al. (1997) studied this question.

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