February 10, 2004Blood

VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis

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Structured PICO

Population

Human umbilical vein endothelial cells (HUVECs)

Intervention

VEGF analogs (VEGF-A165, VEGF-A121), VEGFR-2 inhibitor (SU1498), NRP-1 antagonist (GST-Ex7), and selective PAF receptor antagonists

Comparator

Unstimulated cells or cells treated with different VEGF analogs/inhibitors

Outcome

P-selectin translocation and neutrophil adhesion to activated endothelial cellssurrogate

VEGF-A165 mediates maximal P-selectin translocation and neutrophil adhesion via the VEGFR-2/NRP-1 complex and PAF synthesis in endothelial cells.

No takes yet. Share an insight, caveat, or question.

May inform endothelial targets in inflammation; leaves open human translation from animal models.

Rollin et al. (2004) studied this question.

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