Key result
Median nerve stimulation raises VF threshold ~133% vs vagotomy in a canine MI model.
Why the study?
Median nerve stimulation diminishes regional myocardial ischemia and ventricular arrhythmia, but the underlying mechanism has not been elucidated.
Does median nerve stimulation elevate ventricular fibrillation threshold in a canine model of myocardial infarction?
Does median nerve stimulation elevate ventricular fibrillation threshold in a canine model of myocardial infarction?
Median nerve stimulation increases the ventricular fibrillation threshold in a post-myocardial infarction canine model, potentially via the cholinergic anti-inflammatory pathway.
Answers are grounded in this paper and cite their sources.
May raise VF threshold post-MI in canines; hypothesis-generating and leaves open human translation.
Background Median nerve stimulation (MNS) diminishes regional myocardial ischemia and ventricular arrhythmia; however, the underlying mechanism has not been elucidated. Methods In this study, we randomly categorized 22 adult mongrel dogs into a control group, MNS group 1, and MNS group 2. After a 4-week experimental myocardial infarction (MI), ventricular electrophysiology was measured in the MNS group 1 before and after 30 min of MNS. The same measurements were performed in the MNS group 2 dogs via bilateral vagotomy. Venous blood and ventricular tissue were collected to detect molecular indicators related to inflammation and cholinergic pathways by enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), and Western blot (WB). Results No significant changes were reported in the ventricular effective refractory period (ERP) in the MNS group 1 and MNS group 2 dogs before and after MNS. The ventricular fibrillation threshold (VFT) in the MNS group 1 was significantly higher than that in the MNS group 2 (20.3 ± 3.7 V vs. 8.7 ± 2.9 V, P < 0.01). The levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and nuclear transcription factor-κB (NF-κB) were lower ( P < 0.01), whereas the levels of Ach were higher in the peri-infarct zone tissues in the MNS group 1 dogs than those in the MNS group 2 dogs ( P < 0.01). Conclusion This study demonstrated that MNS increases VFT in a canine model with MI. The effects of MNS on VFT are potentially associated with the cholinergic anti-inflammatory pathway.
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Wang et al. (2022) studied Myocardial infarction (n=22). Median nerve stimulation vs. Bilateral vagotomy before median nerve stimulation was evaluated on Ventricular fibrillation threshold (p=<0.01). Median nerve stimulation significantly increased the ventricular fibrillation threshold to 20.3 V compared to 8.7 V in the vagotomy group in a canine model of myocardial infarction.
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