Why the study?
Does short-term vagal nerve stimulation improve cardiac dysfunction and reduce infarct size in adult male Sprague-Dawley rats with acute myocardial infarction?
Population
Adult male Sprague-Dawley rats subjected to acute myocardial infarction induced by occlusion of the left…
Comparison
Short-term vagal nerve stimulation vs AMI without VNS, VNS without AMI, and control…
Design
Preclinical
Follow-up
4 hours
Authors
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Supports VNS in rat AMI models; hypothesis-generating and requires human trials before any clinical consideration.
Does short-term vagal nerve stimulation improve cardiac dysfunction and reduce infarct size in adult male Sprague-Dawley rats with acute myocardial infarction?
Short-term vagal nerve stimulation during acute myocardial infarction in rats ameliorates cardiac dysfunction and reduces infarct size, partly by inhibiting the TNF-α-mediated inflammatory pathway.
Kong et al. (2011) studied this question.
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