Key result
Coronary vessels with intermediate stenoses and normal FFR (>0.80) frequently exhibited disturbed hemodynamics, with higher microcirculatory resistance than those with FFR≤0.80 (27.6 vs 17.3; P=0.001).
Observational (n=78)
Absolute Event Rate: 27.6% vs 17.3%
p-value: p=0.001
A substantial proportion of coronary arteries with intermediate stenoses and non-ischemic FFR (>0.80) have disturbed hemodynamics, including abnormal CFR and microcirculatory dysfunction.
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Normal FFR may overlook microcirculatory dysfunction in intermediate stenoses; leaves open whether resistance indices refine risk stratification.
Echavarría‐Pinto et al. (2013) conducted an observational in Chronic ischemic heart disease with intermediate coronary stenoses (n=78). Fractional flow reserve (FFR) > 0.80 vs. FFR ≤ 0.80 was evaluated on Index of microcirculatory resistance (IMR) (p=0.001). Coronary vessels with intermediate stenoses and normal FFR (>0.80) frequently exhibited disturbed hemodynamics, with higher microcirculatory resistance than those with FFR≤0.80 (27.6 vs 17.3; P=0.001).
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