Key result
Adjusting fractional flow reserve measurements for hyperaemic microvascular resistance substantially improved its correlation with hyperaemic stenosis resistance (adjusted-r2=0.73, p<0.001).
Why the study?
Does hyperaemic microvascular resistance impact fractional flow reserve measurements and their diagnostic accuracy for myocardial ischaemia in patients with stable coronary artery disease?
Observational (n=178)
Does hyperaemic microvascular resistance impact fractional flow reserve measurements and their diagnostic accuracy for myocardial ischaemia in patients with stable coronary artery disease?
Effect estimate: adjusted-r2 0.73
p-value: p=<0.001
Microvascular resistance obscures the assessment of epicardial disease severity by FFR, highlighting the potential value of combined pressure and flow measurements in clinical practice.
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Microvascular resistance may confound FFR accuracy in stable CAD; leaves open whether combined pressure-flow indices improve ischaemia detection.
Hoef et al. (2014) conducted an observational in Stable coronary artery disease (n=178). Combined intracoronary pressure and flow measurements (FFR, HSR, HMR) was evaluated on Relation between fractional flow reserve (FFR) and hyperaemic stenosis resistance (HSR) (adjusted-r2 0.73, p=<0.001). Adjusting fractional flow reserve measurements for hyperaemic microvascular resistance substantially improved its correlation with hyperaemic stenosis resistance (adjusted-r2=0.73, p<0.001).
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