Why the study?
Does caffeine improve daytime somnolence in patients with Parkinson disease?
RCT (n=61)
Placebo-controlled
randomized
Yes
Does caffeine improve daytime somnolence in patients with Parkinson disease?
Caffeine up to 200 mg twice daily for 6 weeks did not significantly improve excessive daytime sleepiness in Parkinson disease, though it may improve objective motor measures.
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Fine-Edelstein et al. (1994) conducted an RCT in Parkinson disease with daytime somnolence (n=61). Caffeine vs. Matching placebo was evaluated on Epworth Sleepiness Scale score (-1.71 points, 95% CI -3.57, 0.13, p=nonsignificant).
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