Key result
The BE1 +9/+9 genotype was associated with higher systolic blood pressure in white Americans and 25% higher forearm vascular resistance in black Americans.
Why the study?
Does the bradykinin B2 receptor BE1 polymorphism influence blood pressure and vascular resistance in normotensive subjects?
Observational (n=228)
Does the bradykinin B2 receptor BE1 polymorphism influence blood pressure and vascular resistance in normotensive subjects?
The BE1 +9/+9 polymorphism in the bradykinin B2 receptor gene is associated with higher systolic blood pressure in white Americans and higher forearm vascular resistance in black Americans.
Answers are grounded in this paper and cite their sources.
Should not change practice; leaves open whether BE1 polymorphism contributes to hypertension risk or therapy response.
We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114+/-1 and 49+/-1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110+/-2 and 44+/-2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.
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Pretorius et al. (2007) conducted an observational in Normotension (n=228). BE1 +9/+9 genotype vs. BE1 -9/-9 genotype was evaluated on Systolic blood pressure (p=<0.05). The BE1 +9/+9 genotype was associated with higher systolic blood pressure in white Americans and 25% higher forearm vascular resistance in black Americans.
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