Demonstrates the formation of allylic phosphine oxides in propargylic alcohols, suggesting a novel and efficient synthetic pathway.
Allylic phosphorous compounds are a class of important skeletons found in bioactive molecules and ligands. Here, we describe a synthesis of allylic phosphorous compounds from propargylic alcohols and chlorodiarylphosphines via a cascade reaction of OP bond formation/[2,3]‐rearrangement/Michael addition under metal‐free conditions. The reaction conditions are operationally simple and relatively mild, giving 2‐chloro‐allyl‐diarylphosphine oxides in ( E )‐configuration selectively.
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Chen et al. (2026) studied this question.
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