Demonstrates a transition-metal-free method for producing diverse allylic phosphonates, indicating a significant advancement in synthetic chemistry.
The allylic phosphonates are unique reagents for the preparation of dienes and polyenes. Hitherto, there is still no method for the stereodivergent synthesis of allylic phosphonates. In this article, a transition-metal-free method has been developed under mild conditions for the stereodivergent synthesis of allylic phosphonates from readily available dialkyl phosphites, vinyltriphenylphosphonium chloride, and aldehydes. An array of cis- and trans-allylic phosphonates is produced on demand with good to excellent stereoselectivities and yields.
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Zhang et al. (2026) studied this question.
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