Chemo-, Regio- and Stereoselective Synthesis of (E)- γ,γ-Diarylvinylphosphonates from α-Hydroxyallylphosphonates in TFA

Babak Kaboudin; Abolfazl Yadghybi; Hikaru Yanai; Haruhiko Fukaya; Tianjian Zhang; Yanlong Gu

doi:10.1039/d6ob00158k

January 1, 2025Organic & Biomolecular Chemistry

Chemo-, Regio- and Stereoselective Synthesis of (E)- γ,γ-Diarylvinylphosphonates from α-Hydroxyallylphosphonates in TFA

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Key Points

The aim is to develop a mild and efficient protocol for synthesizing γ,γ-diarylvinylphosphonates.
Utilized dehydrative γ-selective arylation of α-hydroxyallylphosphonates with phenols.
Conducted reactions in the presence of TFA (trifluoroacetic acid).
The synthesis occurs smoothly under mild conditions.
Achieved high yields of γ,γ-diarylvinylphosphonates.

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Implication

This research demonstrates a method for synthesizing γ,γ-diarylvinylphosphonates, implying effective application in organic chemistry.

Abstract

We report a mild and efficient protocol for the synthesis of γ,γ-diarylvinylphosphonates via dehydrative γ-selective arylation of α-hydroxyallylphosphonates. The reaction of α-hydroxyallylphosphonates with phenols proceeds smoothly in the presence of...

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Kaboudin et al. (2025) studied this question.

synapsesocial.com/papers/69f2f19c1e5f7920c6387504 https://doi.org/10.1039/d6ob00158k

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Chemo-, Regio- and Stereoselective Synthesis of (E)- γ,γ-Diarylvinylphosphonates from α-Hydroxyallylphosphonates in TFA

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Chemo-, Regio- and Stereoselective Synthesis of (E)- γ,γ-Diarylvinylphosphonates from α-Hydroxyallylphosphonates in TFA

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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