A Mild and DNA-Compatible Cyclization Strategy for the Construction of [1,2,4]Triazolo[1,5- a ]pyridine Scaffolds

Here, we report a mild and DNA-compatible cyclization strategy for the construction of [1,2,4]triazolo[1,5-a]pyridine scaffolds that is well suited for DNA-encoded library (DEL) construction. This reaction proceeds via cyclocondensation of aldehydes with 1,2-diaminopyridinium salt substrates under mild and simple conditions. This method enables the rapid and efficient construction of a series of DNA-encoded libraries containing compounds with a potentially biologically active [1,2,4]triazolo[1,5-a]pyridine scaffold.