Demonstrates iodine-mediated oxidative cyclization for synthesizing triazolopyridines, suggesting efficient methods for drug development.
]pyridine derivatives efficiently. The reaction demonstrated a broad substrate scope, encompassing various aromatic, heteroaromatic, and aliphatic aldehydes as well as functionalized hydrazones, frequently achieving nearly quantitative conversion yields of up to 99%. The compatibility of this method with DNA-encoded library technology (DELT) was validated through amino acid linker studies and qPCR analysis, providing a practical synthetic route from pharmacologically privileged triazolopyridine derivatives to DNA-encoded libraries.
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Hong et al. (2026) studied this question.
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