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Monoclonal gammopathy of undetermined significance (MGUS) can onset as early as the second decade of life, with a significantly higher prevalence and earlier age of onset in Black individuals compared to White and Mexican American individuals. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 27, 2026Blood Cancer JournalOpen Access

Prevalence of monoclonal gammopathy of undetermined significance (MGUS) using a sensitive mass spectrometry assay in young individuals 10–49 years of age: a population-based study from the National Health and Nutritional Examination Survey

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This study aims to assess the prevalence and age of onset of monoclonal gammopathy of undetermined significance (MGUS) in individuals aged 10–49 years, focusing on racial disparities.
Population-based screening using serum samples from 12,378 individuals aged 10-49 from NHANES III.
Sensitive mass spectrometry assay to identify MGUS prevalence in various racial groups.
Data analyzed for age-adjusted prevalence and racial comparisons.
MGUS identified in 1.28% of individuals (177 persons), with prevalence increasing with age: 0.2% (10-19), 0.88% (20-29), 1.46% (30-39), 2.82% (40-49).
Significantly higher age-adjusted prevalence in Black individuals (1.49%) compared to White individuals (0.82%), P < 0.01.
Earlier onset observed in Black individuals, with prevalence rising to 5.2% at ages 40-49, compared to 2.8% in White individuals.

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Implication

Population-based study reveals increased prevalence of MGUS in young Black individuals, highlighting racial disparities.

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/6a168a640c924ddd1bd5912e https://doi.org/10.1038/s41408-026-01518-7

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Prevalence of monoclonal gammopathy of undetermined significance (MGUS) using a sensitive mass spectrometry assay in young individuals 10–49 years of age: a population-based study from the National Health and Nutritional Examination Survey

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Discussion

Implication

Cite This Study

Prevalence of monoclonal gammopathy of undetermined significance (MGUS) using a sensitive mass spectrometry assay in young individuals 10–49 years of age: a population-based study from the National Health and Nutritional Examination Survey

Key Points

Discussion

Implication

Cite This Study

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