What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

Assess the prevalence of monoclonal gammopathy in high-risk populations using advanced screening techniques.

December 8, 2025BloodOpen Access

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Assess the prevalence of monoclonal gammopathy in high-risk populations using advanced screening techniques.
Nationwide, prospective study screening ~30,000 individuals
Utilized mass spectrometry for detection
Genetic ancestry assessed via principal component analysis and k-Nearest Neighbors
Overall MGUS prevalence was 12.6%, with 3,793 identified cases
Higher prevalence in Black individuals (17.8%) compared to Non-Black with family history (14.8%)
Age and Black race were significant predictors of MGUS prevalence

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Prospective screening finds higher monoclonal gammopathy prevalence in Black individuals, suggesting targeted strategies.

Allam et al. (2025) studied this question.

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