What question did this study set out to answer?

To evaluate the association between Duffy genotype and the prevalence of monoclonal gammopathy of undetermined significance (MGUS).

December 8, 2025BloodOpen Access

Risk factors and prevalence of monoclonal gammopathy of undetermined significance (MGUS) by duffy genotype

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To evaluate the association between Duffy genotype and the prevalence of monoclonal gammopathy of undetermined significance (MGUS).
Identified participants from Mass General Brigham Biobank (2010-2021)
Excluded plasma cell malignancy cases prior to screening
Determined Duffy genotype through whole-exome sequencing
Used MALDI-TOF mass spectrometry to quantify monoclonal gammopathies
Performed multiple logistic regression to assess risk factors for MGUS.
Identified 13,861 patients with MGUS testing and Duffy genotyping
CC genotype found in 9.2% of participants, with a significant majority identifying as Black or African American
CC participants showed greater odds of MGUS versus non-CC participants (OR 1.30)
Older age and smoking remained significant risk factors for MGUS in Black participants
CC participants had a higher proportion of IgA isotype but no significant difference in IgM isotype.

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Analysis reveals Duffy genotype and high odds of monoclonal gammopathies in Black patients, highlighting genetic influence on MGUS risk.

Perry et al. (2025) studied this question.

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