Comparative Evaluation of Sticky Bone with Alloplastic Bone Graft in the Treatment of Intrabony Defects: A Randomized Controlled Trial

Injectable platelet-rich fibrin is an autologous liquid platelet concentrate prepared using low-speed centrifugation.Owing to its cellular and fibrin components, it can serve as a biologically IntroductIonPeriodontitis is a biofilm-associated inflammatory disease that results in progressive loss of the tooth-supporting apparatus. 1he objectives of periodontal therapy include control of infection and, where feasible, reconstruction of lost periodontal tissues.Although nonsurgical therapy is essential for inflammation control, surgical regenerative procedures are often required for intrabony defects, particularly when defect morphology is favorable for regeneration. 2Achieving true regeneration-the restoration of bone, cementum, and periodontal ligament-is the ultimate goal of periodontal surgery.Bone loss in periodontitis can occur as either horizontal or vertical (intrabony) defects.Among these, intrabony defects demonstrate a higher potential for regeneration, particularly when the defect morphology and number of osseous walls are favorable. 3Over the past decade, regenerative therapy has evolved from conventional flap debridement and bone grafting to more biologically driven approaches employing growth factors and tissue-engineering techniques. 4Among various biologic mediators, platelet-derived growth factors play a central role in stimulating cellular proliferation and differentiation at the defect site.