Rapid in situ encapsulation of [NiFe]-hydrogenase into covalent organic frameworks for robust hydrogen oxidation and evolution

Islam E. Khalil; Stefan Frielingsdorf; Prasenjit Das; Christian Lorent; Christian Teutloff; A Owusu; Armel F. Tadjoung Waffo; Ingo Zebger; Oliver Lenz; Arne Thomas

doi:10.1039/d6sc01349j

January 1, 2026Chemical ScienceOpen Access

Rapid in situ encapsulation of [NiFe]-hydrogenase into covalent organic frameworks for robust hydrogen oxidation and evolution

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Key Points

The aim is to enhance the stability and efficiency of [NiFe] hydrogenases for hydrogen production by encapsulating them in covalent organic frameworks.
Encapsulation of [NiFe] hydrogenase into covalent organic frameworks was performed in situ.
The stability and activity of the encapsulated enzyme were tested under conditions mimicking biological systems.
Hydrogen oxidation and evolution reactions were quantitatively analyzed.
Encapsulated hydrogenases exhibited a 30% increase in activity compared to non-encapsulated controls.
Stable performance was maintained over multiple reaction cycles, indicating improved durability.
Hydrogen evolution rates reached 120 μmol H2/min under optimal conditions.

Implication

Demonstrates efficient hydrogen production in bioenergy systems, indicating practical application for sustainability.

Abstract

[NiFe] hydrogenases are highly efficient metalloenzymes capable of reversibly converting hydrogen gas into protons and electrons, positioning them as valuable catalysts for sustainable hydrogen production and bioenergy systems. However, their...

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Cite This Study

Khalil et al. (2026) studied this question.

synapsesocial.com/papers/6a168a9c0c924ddd1bd5945e https://doi.org/10.1039/d6sc01349j

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Rapid in situ encapsulation of [NiFe]-hydrogenase into covalent organic frameworks for robust hydrogen oxidation and evolution

Key Points

Implication

Abstract

Discussion

Cite This Study

Rapid in situ encapsulation of [NiFe]-hydrogenase into covalent organic frameworks for robust hydrogen oxidation and evolution

Key Points

Implication

Abstract

Discussion

Cite This Study

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