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Review the use of atomic force microscopy (AFM) to understand cancer mechanics and identify potential biomarkers.

Atomic force microscopy‐based nanomechanical signatures as cancer biomarkers in a nutshell

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Review the use of atomic force microscopy (AFM) to understand cancer mechanics and identify potential biomarkers.
Discusses principles of atomic force microscopy and its application to tumor biopsy analysis.
Highlights emerging techniques for mechanophenotyping in liquid biopsy.
Explores broader applicability, including potential use in pulmonary fibrosis.
Identifies nanomechanical signatures that differentiate cancer states at single-cell and tissue levels.
Presents challenges to clinical translation of AFM techniques for widespread use.

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Review summarizes AFM techniques for cancer diagnosis and extends applications for liquid biopsy, suggesting innovative advances.

Andreas Stylianou (2026) studied this question.

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