Key result
Atomic force microscopy-derived Young's modulus serves as a potential mechanical biomarker for distinguishing cancerous from normal cells and monitoring treatment outcomes.
Why the study?
User-independent, reproducible classification using Young's modulus from AFM nanoindentation remains challenging due to assumptions in traditional mechanics models, sample heterogeneity, tip imperfections, and viscoelasticity.
Young's modulus measured via AFM nanoindentation serves as a potential mechanical biomarker for cancer diagnosis and monitoring treatment response, provided advanced data processing techniques are used.
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AFM Young's modulus may support cancer diagnostics and monitoring; leaves open standardized validation before clinical adoption.
Kontomaris et al. (2025) conducted a review in Cancer. Atomic force microscopy (AFM) nanoindentation was evaluated. Atomic force microscopy-derived Young's modulus serves as a potential mechanical biomarker for distinguishing cancerous from normal cells and monitoring treatment outcomes.
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