Key result
Each 10-mg/dL increase in non-HDL-C over 2.5 years was associated with lower mortality (OR 0.67; 95% CI 0.51-0.88) in high-functioning older adults with baseline total cholesterol 195-244 mg/dL.
Why the study?
Does an increase in serum non-HDL-C reduce adverse health outcomes in high-functioning older adults?
Population
267 high-functioning community-dwelling older adults aged 70 to 79 (random sample from the MacArthur cohort).
Design
Cohort
Follow-up
4.5 years
Authors
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Hypothesis-generating for non-HDL-C trajectories in older adults; does not support changing lipid management.
Cohort (n=267)
Does an increase in serum non-HDL-C reduce adverse health outcomes in high-functioning older adults?
Effect estimate: OR 0.67 (95% CI 0.51-0.88)
Increases in non-HDL cholesterol over time may be associated with reduced mortality and functional decline in high-functioning older adults, challenging traditional lipid-lowering paradigms in this specific population.
Karlamangla et al. (2004) conducted a cohort in High-functioning older adults (n=267). Increase in serum non-high-density lipoprotein cholesterol (non-HDL-C) was evaluated on All-cause mortality in individuals with baseline total cholesterol 195-244 mg/dL (OR 0.67, 95% CI 0.51-0.88). Each 10-mg/dL increase in non-HDL-C over 2.5 years was associated with lower mortality (OR 0.67; 95% CI 0.51-0.88) in high-functioning older adults with baseline total cholesterol 195-244 mg/dL.
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