Key result
Surviving Purkinje fibers in the peri-infarct zone of mouse hearts exhibited slow, non-uniform impulse propagations and beat-to-beat alternans of Ca2+ transient amplitude.
Population
Mouse myocardial infarct models
Comparison
Rapid fluo4-fluorescence imaging by macro-zoom… vs Intact hearts
Design
Preclinical
Authors
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Suggests Purkinje fiber Ca2+ instability as post-MI arrhythmia substrate; hypothesis-generating and requires human validation.
Surviving Purkinje fibers in the peri-infarct zone exhibit non-uniform Ca2+ dynamics, providing a potential substrate for arrhythmogenesis.
Matsuyama et al. (2017) studied Myocardial infarct. Myocardial infarction (left coronary-artery ligation) vs. Intact heart was evaluated on Intracellular Ca2+ dynamics of Purkinje fiber networks. Surviving Purkinje fibers in the peri-infarct zone of mouse hearts exhibited slow, non-uniform impulse propagations and beat-to-beat alternans of Ca2+ transient amplitude.
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