Key result
Confocal laser scanning microscopy and Ca2+-sensitive fluorescent dyes have enabled precise spatiotemporal visualization of intracellular Ca2+ dynamics and abnormal Ca2+ waves in living heart muscle cells.
Population
Living heart muscle cells and whole heart preparations from animal models
Design
Review
Authors
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Enhances research tools for Ca2+ dynamics in cardiomyocytes; leaves open clinical translation to arrhythmia therapies.
Confocal laser scanning microscopy enables precise spatiotemporal visualization of intracellular Ca2+ dynamics, revealing the role of Ca2+ waves and sparks in cardiac arrhythmogenesis and contractile dysfunction.
Tanaka et al. (2003) conducted a review in Intracellular Ca2+ dynamics in cardiomyocytes. Confocal laser scanning microscopy was evaluated. Confocal laser scanning microscopy and Ca2+-sensitive fluorescent dyes have enabled precise spatiotemporal visualization of intracellular Ca2+ dynamics and abnormal Ca2+ waves in living heart muscle cells.
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