September 3, 2015PLoS Computational BiologyOpen Access

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes

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Population

Adult rat left ventricular myocytes

Design

Preclinical

Authors

VRVijay RajagopalAustralian Research Council GBGregory BassCSL (Australia)CWCameron WalkerUniversity of Auckland

Discussion

Member takes

Implication

Subcellular calcium heterogeneities warrant no clinical changes; leaves open their role in human arrhythmias.

Structured PICO

Population

Adult rat left ventricular myocytes (computational model combining confocal-scale data of RyR clusters with 3D electron microscopy data of myofibrils and mitochondria)

Intervention

Hybrid-scale spatial model simulating reaction-diffusion of [Ca2+]i during the rising phase of the transient

Outcome

Simulated reaction-diffusion of [Ca2+]i and fluorescence intensity signal (F/F0) at 30 mssurrogate

A novel hybrid-scale spatial model demonstrates that heterogeneities in cardiomyocyte calcium transients are driven by the spatial distribution of mitochondria and local densities of RyR clusters.

Cite This Study

Rajagopal et al. (2015) studied this question.

synapsesocial.com/papers/6a849a3a85a95bb87468dfd5 https://doi.org/10.1371/journal.pcbi.1004417

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