This study developed methods to quantitatively measure spatiotemporal intramitochondrial calcium gradients during excitation-contraction coupling in cardiac myocytes, revealing higher and faster calcium transients near the Z-line.
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Spatiotemporal mitochondrial Ca2+ gradients in myocytes warrant no clinical action; leaves open their role in human excitation-contraction coupling and energetics.
Lu et al. (2012) studied this question.
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