Population
Single ventricular cardiac myocytes
Design
Preclinical
Authors
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Provides high-resolution insight into sarcomeric Ca2+ gradients; leaves open translation to human EC coupling and disease.
High-speed digital imaging microscopy reveals steep intrasarcomeric calcium gradients during early systole, explaining key features of excitation-contraction coupling in cardiac muscle.
Isenberg et al. (1996) studied this question.
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