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May 25, 2006AJP Cell Physiology

Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes

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Population

Permeabilized cat ventricular myocytes

Design

Preclinical

Authors

MSMarina SedovaLoyola University ChicagoEDElena N. DedkovaCalifornia Northstate UniversityLBLothar A. BlatterElectrophysiology

Discussion

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Implication

May influence frequency-dependent energetics in myocytes; leaves open relevance to human HF or arrhythmias.

Structured PICO

P
Population
Permeabilized cat ventricular myocytes
I
Intervention
Elevation of extramitochondrial Ca2+ (continuous or pulsatile) and manipulation of extramitochondrial Na+
O
Outcome
Mitochondrial Ca2+ concentration ([Ca2+]m) and rate of Ca2+ accumulation/extrusionsurrogate

Mitochondria in cardiac myocytes integrate fast cytosolic Ca2+ transients to produce a frequency-dependent net Ca2+ accumulation rather than tracking beat-to-beat changes.

Cite This Study

Sedova et al. (2006) studied this question.

synapsesocial.com/papers/6a87fb2cb0d802598bf4c9e3https://doi.org/10.1152/ajpcell.00619.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes1991 · 277 citations
  2. 2Changes in mitochondrial calcium concentration during the cardiac contraction cycle1993 · 96 citations
  3. 3Modulation of mitochondrial Ca2+ by nitric oxide in cultured bovine vascular endothelial cells2005 · 51 citations
  4. 4Intracellular [Na<sup>+</sup>] and Na<sup>+</sup> pump rate in rat and rabbit ventricular myocytes2002 · 122 citations
  5. 5Intracellular Sodium Modulates Mitochondrial Calcium Signaling in Vascular Endothelial Cells2000 · 39 citations