Key result
Two-dimensional confocal imaging in rat cardiac myocytes resolved 0.95 +/- 0.13 reproducible focal Ca2+ release sites per cubic micrometer, corresponding to dyadic junctions.
Population
Rat cardiac myocytes
Design
Preclinical
Authors
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Advances dyadic Ca2+ signaling models in myocytes; leaves open clinical translation to arrhythmias or HF.
High-speed 2D confocal imaging in rat cardiac myocytes demonstrates that focal Ca2+ releases occur at discrete sites corresponding to dyadic junctions and operate in a coordinated fashion.
Cleemann et al. (1998) studied this question. Two-dimensional confocal imaging was evaluated on Density and distribution of focal Ca2+ release sites. Two-dimensional confocal imaging in rat cardiac myocytes resolved 0.95 +/- 0.13 reproducible focal Ca2+ release sites per cubic micrometer, corresponding to dyadic junctions.
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