Key result
Long COVID is linked to moderate to severe autonomic dysfunction in 66% of patients.
Why the study?
Autonomic dysfunction is a known complication of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID, but its prevalence, severity, and relation to acute infection severity were unknown.
Cross-Sectional (n=2,314)
Yes
Absolute Event Rate: 28.95% vs 26.4%
p-value: p=0.06
Moderate to severe autonomic dysfunction is highly prevalent in patients with long COVID, independent of the severity of their acute COVID-19 illness.
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Supports autonomic screening in long COVID; leaves open causality and treatment needs.
Larsen et al. (2022) conducted a cross-sectional in Post-acute sequelae of SARS-CoV-2 (PASC) / Long COVID (n=2,314). Hospitalization for acute COVID-19 vs. No hospitalization for acute COVID-19 was evaluated on COMPASS-31 total score (p=0.06). Moderate to severe autonomic dysfunction was present in 66% of patients with long COVID, with symptom severity independent of acute COVID-19 hospitalization status.
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