Key result
Acute, non-critically ill COVID-19 was associated with a significantly higher prevalence of orthostatic hypotension compared to healthy controls (44.7% vs 5.3%, OR 16.00).
Why the study?
Dysautonomic symptoms have been reported in acute COVID-19, but clear evidence is lacking, especially in non-critical forms of the infection.
Does acute, non-critically ill COVID-19 infection increase the prevalence of autonomic dysfunction compared to healthy controls?
Cross-Sectional (n=76)
No
Does acute, non-critically ill COVID-19 infection increase the prevalence of autonomic dysfunction compared to healthy controls?
Odds Ratio: 16 (95% CI 3.22–79.48)
Absolute Event Rate: 44.7% vs 5.3%
p-value: p=0.001
Acute, non-critically ill COVID-19 infection is associated with early autonomic dysfunction, including a significantly higher prevalence of orthostatic hypotension and self-reported dysautonomic symptoms.
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Dysautonomia symptoms and orthostatic hypotension may occur early in non-critical COVID-19; leaves open need for prospective confirmation before screening changes practice.
Scala et al. (2022) conducted a cross-sectional in Acute, non-critically ill COVID-19 (n=76). Acute SARS-CoV-2 infection vs. Healthy volunteers was evaluated on Prevalence of orthostatic hypotension (OR 16.00, 95% CI 3.22-79.48, p=0.001). Acute, non-critically ill COVID-19 was associated with a significantly higher prevalence of orthostatic hypotension compared to healthy controls (44.7% vs 5.3%, OR 16.00).
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