Key result
Initiating antihypertensive therapy with a fixed low-dose combination of perindopril and indapamide normalized blood pressure in 62% of patients, compared to 49% with sequential monotherapy.
Why the study?
Does a fixed low-dose combination of perindopril and indapamide improve blood pressure normalization compared to sequential monotherapy or stepped-care strategies in hypertensive patients?
Does a fixed low-dose combination of perindopril and indapamide improve blood pressure normalization compared to sequential monotherapy or stepped-care strategies in hypertensive patients?
Absolute Event Rate: 62% vs 49%
Fixed low-dose combination therapy with perindopril and indapamide is more effective than sequential monotherapy or stepped-care strategies for achieving blood pressure targets in high-risk hypertensive patients.
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Supports starting with fixed low-dose perindopril-indapamide; leaves open effects on cardiovascular outcomes versus sequential strategies.
Bernard Waeber (2006) conducted a review in Hypertension and Type 2 Diabetes (n=11,140). Perindopril-indapamide fixed low-dose combination vs. Sequential monotherapy (atenolol, losartan, amlodipine) or stepped-care strategy (valsartan, hydrochlorothiazide) was evaluated on Blood pressure normalization (< 140/90 mmHg). Initiating antihypertensive therapy with a fixed low-dose combination of perindopril and indapamide normalized blood pressure in 62% of patients, compared to 49% with sequential monotherapy.
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